[Purpose/significance] The knowledge base plays an important role in emergency response decision-making. It is not only the intellectual support for emergency decision-making, but also the premise of the formation of emergency response information system. To enhance the level of emergency decision-making, it is essential to adapt to the situation of large amount of information, high precision, cross-cutting requirements with more rapid response. Therefore, a knowledge base collaboration framework should be formed to provide emergency solutions in an orderly, efficient, and timely manner. [Method/process] Around the emergency response, it was vital for this paper to comb the demands of the knowledge base from three angles:the public, rescuer and decision makers, and combine them with emergency response in all stages of the process. This paper explored the construction of the knowledge base system framework for emergency response, in accordance with three dimensions of the common sense knowledge, facts and empirical knowledge, and the arithmetic reasoning rules. [Result/conclusion] The framework of the knowledge base system constructed in this paper focuses on the function of universal knowledge from emergency response, and the function of rapid response in the emergency process. The framework of the system consists of three knowledge bases, which are the Common-sense Knowledge Base (c-KB), the Experience Knowledge Base (e-KB), and the Reasoning Knowledge Base (r-KB). Three knowledge bases are set up to provide accurate and timely knowledge support for emergency decision-making.